CCAM Seminar Series - Dr. Ian Wong
CCAM Seminar Series Speaker: Dr. Ian Wong, Associate Professor of Engineering, Associate Professor of Pathology and Laboratory Medicine, Brown University Title: "Mechanobiology and Topology of Collective Cell Migration" Abstract: Complex tissue architectures emerge from the interactions of migratory epithelial cells, driving self-organizing and pattern forming behaviors. In particular, transitions between multicellular groups and individuals (i.e. epithelial-mesenchymal transitions) occur widely in embryonic development, wound healing, and cancer progression. Here, I present my group's work on collective cell migration at the interface of mechanobiology and topology. First, I describe our work on orbiting to invasive transitions of multicellular spheroids in 3D matrix, which we have systematically explored using experiment and computational modeling. Second, I present results on topological data analysis for human interpretable machine learning of multicellular patterns. I highlight the use of persistence diagrams and persistence images for dimensionality reduction and classification of tissue architectures. We envision that these physical and mathematical approaches enable new insights into the complexity of tissue morphogenesis in development and disease. Bio: Ian Wong is Associate Professor of Engineering, and of Pathology / Laboratory Medicine at Brown University. He engineers new miniaturized technologies based on biomaterials and microfluidics to investigate cancer cell invasion, drug resistance, and heterogeneity. He is also interested in the unconventional fabrication of bio and nano materials using self-assembly and 3D printing. He did his graduate work on the directed self-assembly of biomolecular materials with Nick Melosh, receiving a Ph.D. in Materials Science and Engineering from Stanford University. His postdoctoral training was with Mehmet Toner and Daniel Irimia at the Center for Engineering in Medicine at Massachusetts General Hospital. Location: CGSB Grossman Auditorium Via Webex: https://uchc.webex.com/uchc/j.php?MTID=mac08cf7c2a074edebb81c5014fa956e6 (https://uchc.webex.com/uchc/j.php?MTID=mac08cf7c2a074edebb81c5014fa956e6) Meeting number (access code): 2632 055 2912 Meeting password: CCAMseries Guest Host: Dr. Abhi Deb Roy