Michael GuertinAssociate Professor, UConn Health Host: Leighton CoreMechanisms of direct repression by a transcription activatorThe term context specific is often vaguely invoked to describe transcription factors that have both activation and repression functions. In the seminar, I will define the context and molecular mechanisms of transcription factor-mediated cis activation and repression.Bio: Coordinate transcription regulation is central to development, drug responses, environmental feedback, and transcriptional dysregulation can lead to disease. The Guertin lab's greatest contribution to science has been to define the rules by which transcription factors determine where to bind in the genome and how transcription factors discriminate between genes to regulate.Link to publication (https://doi.org/10.1101/2024.05.13.594008)Guertin Lab Website (http://www.guertinlab.org)